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Labelling on cardboard packaging, boxes and cases

Cardboard-based packaging is used throughout the entire pharmaceutical journey from production to patient. From the individual pharmaceutical box containing blisters or bottles, to shipping cartons and pallet labelling – each packaging level has its own function and therefore its own labelling requirements.
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Pharmaceutical carton ink marking

Different techniques for Cardboard packaging, boxes and cases

Pharmaceutical carton ink marking
Pharmaceutical carton ink marking
Pharma product labelling on boxes
Pharma product labelling on boxes

Inkjet printing

When it comes to labelling pharmaceutical boxes, Thermal Inkjet (TIJ) is the most widely used technology.

The main reason is the print quality. Medicine boxes often contain:

  • batch number
  • expiration date
  • Datamatrix codes
  • Serial Number

The information should not only be readable. It should be verifiable by vision cameras and meet the quality requirements set by GS1 and the serialization systems.

Here TIJ offers several important advantages. The high resolution makes it possible to write very small characters with high contrast.

Since pharmaceutical cartons also have a very high material quality, good conditions are created for smooth and reproducible prints.

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Pharma product labelling on tablet medicine
Pharma product labelling on tablet medicine
Pharma product labelling on boxes
Industrial laser printer - laser marking on plastic cork
Pharma product labelling on tubes of medicine

Laser marking

Lasers are also used for cardboard packaging in the pharmaceutical industry. The advantage is that the marking becomes permanent while eliminating the need for ink and other consumables.

But the choice of laser is primarily determined by the cardboard material. Not all cardboard reacts the same to lasers.

Surface finish, color, coating and the structure of the board affect both contrast and readability. Therefore, material tests are normally carried out before a laser solution is selected.

If the cardboard is adapted for laser marking, the technology can provide very high quality for, for example:

  • batch number
  • expiration date
  • Serial Number
  • Datamatrix codes

At the same time, laser integration requires more installation space and a higher level of security than ink-based solutions.

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Pharma product labelling on boxes seal labels, security label
Pharma product labelling on boxes seal labels, security label
Pharma product labelling on boxes seal labels, security label
Pharma product labelling on boxes seal labels, security label

Labelling

Labels are also used in the pharmaceutical industry. This is especially true when:

  • the information varies a lot
  • multiple languages ​​should be handled
  • logistics information to be added
  • shipping cartons should be identified

On shipping cartons, labels are often used as the primary information carrier. Here, the label may contain:

  • SSCC
  • barcodes
  • GS1 information
  • delivery address
  • customer-specific information

Since the shipping carton is not exposed to the end customer, the requirements for the visual impression are normally lower than on the pharmaceutical box.

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Read more about Cardboard packaging, boxes and crates

Cardboard-based packaging is used throughout the entire pharmaceutical journey from production to patient. From the individual pharmaceutical box containing blisters or bottles, to shipping cartons and pallet labelling – each packaging level has its own function and therefore its own labelling requirements.

Although all packaging is made of cardboard, the labelling requirements differ significantly between the different levels. A pharmaceutical box must be individually identifiable and often contains serialized information that is verified mechanically. A shipping carton, on the other hand, has the task of identifying a larger number of products during storage and distribution.

The choice of technology for marking cardboard packaging, boxes and cases is therefore not determined by the fact that the material is cardboard, but by the function of the packaging in the production and distribution chain. Based on our experience, it is precisely this difference that often determines which solution will be the most reliable and cost-effective.

The medicine box – the most important information carrier

The cardboard box that meets the end customer is much more than protective packaging.

It works simultaneously as:

  • product identification
  • information carrier
  • traceability carrier
  • regulatory labelling
  • marketing

Here you will find, among other things:

  • product name
  • strength
  • pharmaceutical form
  • manufacturer
  • batch number
  • expiration date
  • Datamatrix code
  • Serial Number

Unlike blister packaging, the pharmaceutical box is often the packaging that is identified throughout the distribution chain. This also means that the requirements for print quality are very high.

The biggest challenges are rarely about the labelling itself

When discussing labelling on cardboard packaging, boxes and cases, the focus often ends up being on which printer to use. In practice, this is rarely the biggest challenge. The real challenge is instead how to integrate the labelling system into the existing production line.

We often encounter situations where:

  • the products come out in the wrong orientation for labelling
  • the marking was previously done manually
  • there is no space for new equipment
  • the printer must be integrated between existing machines
  • the product flow needs to be automated

In many cases, the project is therefore as much about material handling and machine integration as it is about the marking technology itself.

Product orientation often determines the entire solution

A cardboard box may leave the carton upright. The next machine may require it to be laid down. The vision camera may need to see a specific side. The print head may need to access the top.

This means that the marking often affects how the entire conveyor path must be designed. In some cases, the product needs to be rotated. In other cases, guides or conveyors are rebuilt to create the correct orientation before marking occurs. This is why two seemingly identical cartons can require completely different marking solutions.

Production rate is rarely the limiting factor

Unlike labelling small vials or ampoules, speed is rarely the biggest challenge when labelling cartons, boxes and cases. The reason is simple. The cartons are typically produced after the filling and packaging process.

Carton erectors, carton sealers and packaging machines generally operate at a significantly slower rate than the filling line itself. This means that in most cases the labelling system has plenty of time to apply and verify the labelling. Instead, the focus shifts to:

  • correct product positioning
  • verification
  • integration
  • recipe control
  • operator friendliness

Questions & Answers (FAQ)

For most pharmaceutical packaging, ink marking is recommended due to its flexibility and high contrast. For permanent solutions that will withstand wear and tear, laser is the best option.
Yes. With the right choice of ink or laser setting, it is possible to create sharp, readable codes even on laminated surfaces. Our systems are always tested on the customer's material to ensure optimal adhesion and contrast.
Legibility is guaranteed through high-resolution marking (minimum 300 dpi) and quality control in line with ISO/GS1 standards. We also offer verification systems that check each code in real time.
Yes. Laser marking is an established and accepted method in the pharmaceutical industry, especially for traceability codes and permanent batch markings. It also provides environmentally friendly and maintenance-free operation without ink or consumables.
Our labelling solutions are tailored to comply with the EU’s Falsified Medicines Directive (FMD). This means that each package can be labeled with a unique identification, batch information and Datamatrix code that can be traced throughout the entire supply chain.
Yes. Our inkjet and laser systems can be easily adapted for both primary packaging (small boxes) and secondary packaging (outer cartons), providing consistent labelling throughout production.

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